The delightful caption is at first blush, sophomoric, yet witty. To those with even the most rudimentary grasp of the life sciences, though, the caption remains sophomoric, but unfortunately, invalid. You seem to have forgotten that human beings are Deuterostomes. For those lower forms of life perusing this so-called "blog", this a taxonomic classification (derived from the Greek Deuterostomia - meaning "second mouth"). During the process of enterocoely (an early stage of development), the mouth and anus are formed. So it is elementary that all humans have at least two "holes". Approximately half of all humans (specifically, females), have another "hole of interest", the vagina (from the Latin "sheath"). I believe you were referencing this "hole" as one of the two raised fingers (by the females in the picture), to distinguish the difference between males and females, which to your credit, is actually correct. However, due to either your lack of patince to actually think your joke through, or total ignorance of biology, the caption fails to amuse those who may be considered at least moderately learned. The conclusion drawn here is that in actuality, the only "hole" associated with this "cartoon" is you, tough guy.

"Gaseous Clay" what a witty name Hardy har, har! -_-

sorry we arent moderately learned you cumslug. I bet you go around writing on these things all day and discuss the finer points of john leguizamo's portrayal as luigi with your mother while bashing your son's head in with a blunt object. some one writes a fucking joke under a caption and bill kurtis over here tries to ruin it with his big fancy words backed up with female anatomy knowledge. I bet you are a pussy magnet guy. And dont write anything back, because there isnt a cold chance in hell I am coming to this website after reading what Stephen Hawking over here wrote.

Dear angry awesome kid,

All these posters are my friends (except you). Abuse them not, and leave here in peace.

Signed, OP

Dear Earth,

All these worlds are yours (except Europa). Use them together, use them in peace.

Signed,
Large Rectangular Black Thing

Wow. I didn't really think you could get so many retards to assemble in the same place. You people suck and should get over yourselves. By the way gaseous, guys have two holes, and girls three (you forget about the mouth, the same part of your body that obnoxious bullshit is coming from).

It's not that serious, funny caption, and it made me laugh. Soooo, what's the issue here?
Keep it up :)